Two friends spend all their free time building flame-throwers and weapons of mass destruction in hopes that a global apocalypse will occur and clear the runway for their imaginary gang "Mother Medusa".
In London, a mother and daughter navigate their respective romances; Madeline rekindles an affair from thirty years earlier, while her daughter Vera is caught between a musician who cannot commit and her ex, who still pines for her.
Toward the end of his life F. Scott Fitzgerald is writing for Hollywood studios to be able to afford the cost of an asylum for his wife. He is also struggling against alcoholism. Into his life comes the famous gossip columnist.